Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1865

Review

Martinez-Moreno, D.^1,2  Jimenez, G.^1,2,3,4  Galvez-Martin, P.^5,7  Rus, G.^1,2,6  Marchal, J. A.^1,2,3,4 

[1] Univ Granada, Biopathol & Regenerat Med Inst IBIMER, Ctr Biomed Res, E-18100 Granada, Spain

[2] Univ Granada, Excellence Res Unit Modeling Nat MNat, Granada, Spain

[3] Univ Granada, Biosanitary Res Inst Granada Ibs GRANADA, Univ Hosp Granada, E-18071 Granada, Spain

[4] Univ Granada, Dept Human Anat & Embryol, Fac Med, E-18016 Granada, Spain

[5] Bioiberica SAU, Pharmasci Div, Adv Therapies Area, E-08029 Barcelona, Spain

[6] Univ Granada, Dept Struct Mech, Politecn Fuentenueva, E-18071 Granada, Spain

[7] Univ Granada, Dept Pharm & Pharmaceut Technol, Fac Pharm, E-18071 Granada, Spain

关键词: Mechanotransduction;    Biomechanics;    Osteoarthritis;    Ultrasound;    Tissue engineering;    Regenerative medicine;   

DOI  :  10.1016/j.bbadis.2019.03.011

来源: Elsevier

【 摘 要 】

Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in tissue development. This review describes how physics alters cartilage and its extracellular matrix (ECM); and its role in OA development. The ECM of the articular cartilage (AC) is widely involved in cartilage turnover processes being crucial in regeneration and joint diseases. We also review the importance of physicochemical pathways following the external forces in AC. Moreover, new techniques probed in cartilage tissue engineering for biomechanical stimulation are reviewed. The final objective of these novel approaches is to create a cellular implant that maintains all the biochemical and biomechanical properties of the original tissue for long-term replacements in patients with OA.

【 授权许可】

Free