Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1863

Review

Bhatti, Jasvinder Singh^1,2  Bhatti, Gurjit Kaur³  Reddy, P. Hemachandra^{2,4,5,6,7,8,9} 

[1] Sri Guru Gobind Singh Coll, Dept Biotechnol & Bioinformat, Sect 26, Chandigarh 160019, India

[2] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

[3] Panjab Univ, UGC Ctr Excellence Nano Applicat, UIPS Bldg, Chandigarh 160014, India

[4] Texas Tech Univ, Hlth Sci Ctr, Cell Biol & Biochem Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

[5] Texas Tech Univ, Hlth Sci Ctr, Neurosci & Pharmacol Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

[6] Texas Tech Univ, Hlth Sci Ctr, Neurol Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

[7] Texas Tech Univ, Hlth Sci Ctr, Speech Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

[8] Texas Tech Univ, Hlth Sci Ctr, Language & Hearing Sci Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA

[9] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, South West Campus,6630 S Quaker Suite E,MS 7495, Lubbock, TX 79413 USA

关键词: Metabolic syndrome;    Mitochondria;    Oxidative stress;    Reactive oxygen species;    Mitochondria-targeted antioxidants;    Cardiovascular disease;    Pre-diabetes;    Type-2-diabetes;    Obesity;   

DOI  :  10.1016/j.bbadis.2016.11.010

来源: Elsevier

【 摘 要 】

Mitochondria are the powerhouses of the cell and are involved in essential functions of the cell, including ATP production, intracellular Ca2+ regulation, reactive oxygen species production & scavenging, regulation of apoptotic cell death and activation of the caspase family of proteases. Mitochondrial dysfunction and oxidative stress are largely involved in aging, cancer, age-related neurodegenerative and metabolic syndrome. In the last decade, tremendous progress has been made in understanding mitochondrial structure, function and their physiology in metabolic syndromes such as diabetes, obesity, stroke and hypertension, and heart disease. Further, progress has also been made in developing therapeutic strategies, including lifestyle interventions (healthy diet and regular exercise), pharmacological strategies and mitochondria-targeted approaches. These strategies were mainly focused to reduce mitochondrial dysfunction and oxidative stress and to maintain mitochondrial quality in metabolic syndromes. The purpose of our article is to highlight the recent progress on the mitochondrial role in metabolic syndromes and also summarize the progress of mitochondria-targeted molecules as therapeutic targets to treat metabolic syndromes. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases- edited by P. Hemachandra Reddy. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free