The intestinal microenvironment in sepsis

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1863

Article

Fay, Katherine T.¹  Ford, Mandy L.^1,2  Coopersmith, Craig M.^1,3 

[1] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Emory Transplant Ctr, Atlanta, GA USA

[3] Emory Univ, Sch Med, Emory Crit Care Ctr, Atlanta, GA USA

关键词: Sepsis;    Microbiome;    Immune system;    Intestine;    Epithelium;    Gut;   

DOI  :  10.1016/j.bbadis.2017.03.005

来源: Elsevier

【 摘 要 】

The gastrointestinal tract has long been hypothesized to function as the motor of multiple organ dysfunction syndrome. The gastrointestinal microenvironment is comprised of a single cell layer epithelia, a local immune system, and the microbiome. These three components of the intestine together play a crucial role in maintaining homeostasis during times of health. However, the gastrointestinal microenvironment is perturbed during sepsis, resulting in pathologic changes that drive both local and distant injury. In this review, we seek to characterize the relationship between the epithelium, gastrointestinal lymphocytes, and commensal bacteria during basal and pathologic conditions and how the intestinal microenvironment may be targeted for therapeutic gain in septic patients.

【 授权许可】

Free