An efficient one-pot access to trithiocarbonate-tethered peptidomimetics

TETRAHEDRON LETTERS

卷:51

Article

Narendra, N.¹  Lalithamba, H. S.¹  Sureshbabu, Vommina V.¹ 

[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India

关键词: Peptidomimetics;    Amino alkyl thiols;    Carbon disulfide;    Trithiocarbonates;   

DOI  :  10.1016/j.tetlet.2010.09.075

来源: Elsevier

【 摘 要 】

A simple protocol for the synthesis of a new class of trithiocarbonate-linked peptidomimetics and neoglycosylated amino acids is described. N-Protected amino alkyl thiols were treated with CS2 in the presence of triethylamine (TEA) to generate trithiocarbonate salt, which upon reaction with appropriate halides afforded dipeptidomimetics in good yields. Further, the procedure was also extended for the synthesis of N,N'-orthogonally protected trithiocarbonate-linked dipeptidomimetics. (C) 2010 Elsevier Ltd. All rights reserved.

【 授权许可】

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