Enantioselective total synthesis of (-)-ericanone

TETRAHEDRON LETTERS

卷:54

Article

Dias, Luiz C.¹  Kuroishi, Paula K.¹  Polo, Ellen C.¹  de Lucca, Emilio C., Jr.¹ 

[1] Univ Estadual Campinas, UNICAMP, Inst Quim, BR-13084971 Campinas, SP, Brazil

关键词: Total synthesis;    Natural product;    (-)-Ericanone;    Aldol reaction;    Boron enolate;   

DOI  :  10.1016/j.tetlet.2012.12.033

来源: Elsevier

【 摘 要 】

The first total synthesis of (-)-ericanone was achieved in 10 steps with a 16% overall yield from p-hydroxybenzaldehyde. Notable features of this stereocontrolled approach include a Keck allylation to install the stereocenter at C3 and a 1,5-anti aldol reaction to install the hydroxyl group at C7. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free