Metal-free asymmetric hydrogenation and hydrosilylation catalyzed by frustrated Lewis pairs

TETRAHEDRON LETTERS

卷:55

Article

Feng, Xiangqing¹  Du, Haifeng¹ 

[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

关键词: Metal-free;    Asymmetric hydrogenation;    Asymmetric hydrosilylation;    Frustrated Lewis pairs;   

DOI  :  10.1016/j.tetlet.2014.10.138

来源: Elsevier

【 摘 要 】

The activation of H-2 for the catalytic hydrogenation of unsaturated compounds is one of the most useful reactions in both academia and chemical Industry, which has long been predominated by the transition-metal catalysis. However, metal-free hydrogen activation represents a formidable challenge, and has been less developed. The recent emerging chemistry of frustrated Lewis pairs (FLPs) with a combination of sterically encumbered Lewis acids and Lewis bases provides a promising approach for metal-free hydrogenation due to their amazing abilities for the challenging H-2 activation. In the past several years, the hydrogenation of a wide range of unsaturated compounds using FLP catalysts has been successfully developed. Despite these advances, the corresponding asymmetric hydrogenation is just in its start-up step. Similar to the mode of H H bond activation, Si H bond can also be activated by FLPs for the hydrosilylation of ketones and imines. But its asymmetric version is also not well-solved. This Letter will outline the recent important progress of metal-free catalytic asymmetric hydrogenation and hydrosilylation using FLP catalysts. (C) 2014 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free