One-pot synthesis of polycyclic isoindolines using isoindole umpolung

TETRAHEDRON LETTERS

卷:61

Article

Weintraub, Rachel A.¹  He, Wei¹  Wang, Xiang¹ 

[1] Univ Colorado, Dept Chem, Boulder, CO 80309 USA

关键词: Umpolung;    Isoindole;    Cyclization;    One-pot reaction;   

DOI  :  10.1016/j.tetlet.2020.152128

来源: Elsevier

【 摘 要 】

Using an isoindole umpolung strategy, a one-pot synthesis of polycyclic isoindolines was accomplished. In this reaction, the in situ-generated nucleophilic isoindoles were converted to electrophilic isoindoliums via protonation, which underwent a Pictet-Spengler-type cyclization to afford a variety of polycyclic isoindolines in good yields. (C) 2020 Elsevier Ltd. All rights reserved.

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