Kingamide A, a new indole alkaloid from the ascidian Leptoclinides kingi

TETRAHEDRON LETTERS

卷:52

Article

Liberio, Michelle S.¹  Sooraj, Dhanya²  Williams, Elizabeth D.²  Feng, Yunjiang¹  Davis, Rohan A.¹ 

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Monash Univ, Ctr Canc Res, Monash Inst Med Res, Clayton, Vic 3168, Australia

关键词: Kingamide A;    Natural product;    Alkaloid;    Ascidian;    Leptoclinides kingi;   

DOI  :  10.1016/j.tetlet.2011.09.151

来源: Elsevier

【 摘 要 】

Chemical investigation of the CH2Cl2/MeOH extract from the Australian ascidian Leptoclinides kingi led to the isolation of a new brominated indole alkaloid, kingamide A (1). The planar structure of kingamide A was elucidated following the interpretation of 1D/2D NMR and MS data, and the absolute configuration was determined using Marfey's method. This is the first report of a natural product from L. kingi. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

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