An efficient procedure for the preparation of natural products bearing the 2-(2-phenylethyl)chromone skeleton

TETRAHEDRON LETTERS

卷:54

Article

Williams, Dwight A.^1,2  Smith, Cameron²  Zhang, Yan³ 

[1] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

[2] Lynchburg Coll, Dept Chem, Lynchburg, VA 24501 USA

[3] Virginia Commonwealth Univ, Dept Med Chem, Richmond, VA 23298 USA

关键词: 2-(2-Phenylethyl)chromones;    Claisen condensation;    Neuroprotection;    Chromenes;   

DOI  :  10.1016/j.tetlet.2013.06.006

来源: Elsevier

【 摘 要 】

Several 2-(2-phenylethyl)chromones have been shown to possess neuroprotective activity. However, limited synthetic methods have been disclosed to construct the 2-(2-phenylethyl)chromone skeleton. Herein, we report a straightforward 3-step preparation of five naturally occurring 2-(2-phenylethyl)chromones utilizing the Claisen condensation as the key step. Published by Elsevier Ltd.

【 授权许可】

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