Efficient route to pre-organized and linear polyaminopolycarboxylates: Cy-TTHA, Cy-DTPA and mono/di- reactive, tert-butyl protected ITHA/Cy-TTHA

TETRAHEDRON LETTERS

卷:58

Article

Mohamadi, Ali¹  Miller, Lawrence W.¹ 

[1] Univ Illinois, Dept Chem, 845 W Taylor St,MC 111, Chicago, IL 60607 USA

关键词: Chelators;    Lanthanides;    Ligand design;   

DOI  :  10.1016/j.tetlet.2017.02.056

来源: Elsevier

【 摘 要 】

Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from commercially available starting materials in similar to 62% and 47% overall yields, respectively. Furthermore, strategies are reported for the efficient preparation of mono- and di-reactive, tert-butyl-protected TTHA/Cy-TTHA to selectively functionalize central chelators' carboxylic acids. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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