Iron-catalyzed δ-selective conjugate addition of methyl and cyclopropyl Grignard reagents to α,β,γ,δ-unsaturated esters and amides

TETRAHEDRON LETTERS

卷:60

Article

Sugano, Goshi¹  Kawada, Kojiro¹  Shigeta, Masayuki¹  Hata, Takeshi¹  Urabe, Hirokazu¹ 

[1] Tokyo Inst Technol, Sch Life Sci & Technol, Midori Ku, 4259-B-59 Nagatsuta Cho, Yokohama, Kanagawa 2268501, Japan

关键词: Catalytic reaction;    Conjugate addition;    Cyclopropane;    Grignard reagent;    Iron;    Methylation;   

DOI  :  10.1016/j.tetlet.2018.12.043

来源: Elsevier

【 摘 要 】

Iron-catalyzed delta-selective conjugate addition of methyl and cyclopropyl Grignard reagents to alpha,beta,gamma,delta-unsaturated esters and amides took place in good yields to give products exclusively with cis-beta,gamma-olefinic bond. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

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