SNAr azidation of phenolic functions utilizing diphenyl phosphorazidate

TETRAHEDRON LETTERS

卷:61

Article

Ishihara, Kotaro¹  Shioiri, Takayuki¹  Matsugi, Masato¹ 

[1] Meijo Univ, Fac Agr, Tempa Ku, 1-501 Shiogamaguchi, Nagoya, Aichi 4688502, Japan

关键词: SNAr reaction;    Azidation;    Diphenyl phosphorazidate;    Aryl azide;   

DOI  :  10.1016/j.tetlet.2019.151493

来源: Elsevier

【 摘 要 】

A useful method for the synthesis of aryl azides via SNAr reaction of phenol derivatives using diphenyl phosphorazidate (DPPA) as an azidation reagent was developed. Various phenol derivatives bearing electron-withdrawing groups were converted into the corresponding aryl azides in a single step. This method is easy to perform and enables the preparation of aryl azides without the use of explosive azide sources. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

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