Progress toward the synthesis of Urukthapelstatin A and two analogues

TETRAHEDRON LETTERS

卷:53

Article

Pan, Chung-Mao²  Lin, Chun-Chieh²  Kim, Seong Jong¹  Sellers, Robert P.²  McAlpine, Shelli R.¹ 

[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia

[2] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA

关键词: Urukthapelstatin A;    Heterocycles;    Thiazole;    Oxazole;    Hantzsch;    Macrocycle;    Natural product;    Cytotoxicity;   

DOI  :  10.1016/j.tetlet.2012.05.105

来源: Elsevier

【 摘 要 】

We report our progress toward the synthesis of Urukthapelstatin A (Ustat A) and two analogues. Our retrosynthetic strategy involved the synthesis of three fragments: a tri-heteroaromatic moiety, a phenyl oxazole fragment, and a dipeptide. Described are the syntheses of three unique tri-heteroaromatic moieties. In addition, the corresponding linear precursors of Ustat A and two analogues are presented. (C) 2012 Elsevier Ltd. All rights reserved.

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