A convenient approach to the design and synthesis of indolo[3,2-c]coumarins via the microwave-assisted Cadogan reaction

TETRAHEDRON LETTERS

卷:54

Article

Irgashev, Roman A.¹  Karmatsky, Arseny A.¹  Slepukhin, Pavel A.¹  Rusinov, Gennady L.^1,2  Charushin, Valery N.^1,2 

[1] Russian Acad Sci, I Postovsky Inst Organ Synth, Ural Div, Ekaterinburg 620041, Russia

[2] Ural Fed Univ, Ekaterinburg 620002, Russia

关键词: Indolo[3,2-c]coumarins;    3-Aryl coumarins;    Salicylaldehydes;    Cadogan reaction;    Microwave-assisted synthesis;    Reductive cyclization;   

DOI  :  10.1016/j.tetlet.2013.08.030

来源: Elsevier

【 摘 要 】

3-(4,5-Dimethoxy-2-nitrophenyl)coumarins bearing various substituents on the benzene ring of the coumarin system have been prepared from salicylaldehydes and 2-(4,5-dimethoxy-2-nitrophenyl)acetonitrile by means of the Perkin condensation. Further cyclization of these 3-aryl coumarins through the microwave-assisted Cadogan reaction afforded the corresponding indolo[3,2-c]coumarins in good to excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free