One-pot synthesis of orthogonally protected dipeptide selenazoles employing Nα-amino selenocarboxamides and α-bromomethyl ketones

TETRAHEDRON LETTERS

卷:55

Article

Madhu, Chilakapati¹  Panguluri, Nageswara Rao¹  Narendra, N.²  Panduranga, V.¹  Sureshbabu, Vommina V.¹ 

[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India

[2] Tumkur Univ, Govt Sci Coll, Dept Chem, Tumkur 572103, India

关键词: Amino nitrile;    Phosphorus pentaselenide;    N-alpha-Amino selenocarboxamide;    alpha-Bromomethyl ketone;    Selenazole;   

DOI  :  10.1016/j.tetlet.2014.10.085

来源: Elsevier

【 摘 要 】

A simple and efficient protocol for the synthesis of selenazole containing dipeptidomimetics using N-alpha-amino selenocarboxamides and alpha-bromomethyl ketones is described. All the compounds made were isolated in good yields and fully characterized. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free