Modular synthesis of mono, di, and tri-1,4-disubstituted-1,2,3-triazoles through copper-mediated alkyne-azide cycloaddition

TETRAHEDRON LETTERS

卷:52

Article

Stefani, Helio A.¹  Canduzini, Hugo A.¹  Manarin, Flavia¹ 

[1] Univ Sao Paulo, Dept Farm, Fac Ciencias Farmaceut, BR-05508 Sao Paulo, Brazil

关键词: Click chemistry;    1,2,3-Triazole;    Cycloaddition;    Propargyl alcohol;    Ultrasound;   

DOI  :  10.1016/j.tetlet.2011.09.004

来源: Elsevier

【 摘 要 】

The synthesis of 1,2,3-triazoles was developed employing sequential copper azide-alkyne cycloaddition, tosylation, sodium azide, and copper azide-alkyne steps. This approach allowed the synthesis of two and three 1,2,3-triazole rings. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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