A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

TETRAHEDRON LETTERS

卷:53

Article

Petit, Laurent¹  Botez, Iuliana²  Tizot, Andre²  Zard, Samir Z.¹ 

[1] Ecole Polytech, UMR CNRS 7652, Lab Synth Organ, F-91128 Palaiseau, France

[2] Inst Rech Servier IdRS, F-78290 Croissy Sur Seine, France

关键词: Radical cyclisation;    Radical addition;    Xanthates;    Pyridoazepinones;    Peroxides;   

DOI  :  10.1016/j.tetlet.2012.04.020

来源: Elsevier

【 摘 要 】

Variously substituted novel dihydropyridoazepinones have been prepared by an intermolecular radical addition followed by a radical cyclisation on a pyridine ring. The latter process involved the use of a combination of two different peroxides, an experimental contrivance resulting from a careful product analysis and a better understanding of the cyclisation step. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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