New naturally occurring diacetylenic spiroacetal enol ethers from Artemisia selengensis

TETRAHEDRON LETTERS

卷:57

Article

Wang, Kelvin D. G.¹  Wang, Junsong²  Xie, Sai-Sai¹  Li, Zhong-Rui¹  Kong, Ling-Yi¹  Luo, Jun¹ 

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[2] Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing 210094, Jiangsu, Peoples R China

关键词: Artemisia selengensis;    Polyacetylenes;    Diacetylenic spiroacetal enol ethers;    Neuroprotection;    Inhibition of hMAOs;   

DOI  :  10.1016/j.tetlet.2015.11.049

来源: Elsevier

【 摘 要 】

Three new diacetylenic spiroacetal enol ethers, artemiselenols A-C (1-3), were isolated from whole plants of Artemisia selengensis Turcz (Compositae). The structures of all compounds were elucidated on the basis of extensive spectroscopic methods and confirmed by the X-ray crystallographic diffraction of 1. Artemiselenol A is a new naturally occurring polyacetylene containing chlorine, and its absolute configuration was determined as 2S, 5S, 65 and 7R by its X-ray crystallographic diffraction, and those of the rest of the compounds were determined by comparison of their CD spectra. All isolates were screened and evaluated for neuroprotection and inhibition of hMAOs. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

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