Enantioselective synthesis of diarylcyclopropanecarboaldehydes by organocatalysis

TETRAHEDRON LETTERS

卷:57

Article

Chen, Xuyun^1,2  Yu, Yang^1,2  Liao, Ziyang^1,2  Li, Hao^1,2  Wang, Wei^1,2,3 

[1] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China

[3] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

关键词: Diarylyclopropane;    Enantioselective;    Organocatalysis;    Benzyl chloride;    Cinnamaldehyde;   

DOI  :  10.1016/j.tetlet.2016.10.097

来源: Elsevier

【 摘 要 】

An efficient synthetic method for chiral trisubstituted diarylcyclopropanecarboaldehydes has been developed from substituted benzyl chloride and alpha,beta-unsaturated aldehydes. The reactions were catalyzed by chiral amine catalyst under mild condition to afford the chiral diarylcyclopropanecarboaldehydes in good to high yields and up to excellent enantioselectivities. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free