A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation

TETRAHEDRON LETTERS

卷:58

Article

Pandya, Amit N.¹  Villa, Eric M.²  North, E. Jeffrey¹ 

[1] Creighton Univ, Sch Pharm & Hlth Profess, Dept Pharm Sci, Omaha, NE 68178 USA

[2] Creighton Univ, Dept Chem, Omaha, NE 68178 USA

关键词: Quinazolines;    Oxidative annulation;    Metal free;    Heteroaromatic;   

DOI  :  10.1016/j.tetlet.2017.02.033

来源: Elsevier

【 摘 要 】

A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for scale up synthesis and ligand diversity. Notably, this methodology allows for the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

Free