Strong enhancement of two-photon absorption properties in synergic 'semi-disconnected' multiporphyrin assemblies designed for combined imaging and photodynamic therapy

TETRAHEDRON LETTERS

卷:54

Article

Mongin, Olivier^1,2  Sankar, Muniappan¹  Charlot, Marina¹  Mir, Youssef¹  Blanchard-Desce, Mireille^1,3 

[1] Univ Rennes 1, Chim & Photon Mol CNRS UMR 6510, F-35042 Rennes, France

[2] Univ Rennes 1, Inst Sci Chim Rennes CNRS UMR 6226, F-35042 Rennes, France

[3] Univ Bordeaux, Inst Sci Mol CNRS UMR 5255, F-33405 Talence, France

关键词: Sonogashira coupling;    Porphyrin;    Photosensitizer;    Singlet oxygen;    Fluorescence;    Two-photon absorption (2PA);   

DOI  :  10.1016/j.tetlet.2013.09.076

来源: Elsevier

【 摘 要 】

The synthesis and photophysical properties of new multiporphyrin assemblies are described. Their design, based on a smooth electronic disconnection between two-photon absorbing (2PA) octupolar or quadrupolar cores and the peripheral porphyrins, leads to a major increase in (non-resonant) 2PA responses in the NIR, while fully retaining the fluorescence and photosensitization properties of isolated porphyrins. This approach, which involves electronic coupling of semi-disconnected moieties in the higher excited states of the synergic systems, is of interest to fully benefit from the advantages of selective 2PA for application in combined two-photon high resolution imaging and photodynamic therapy. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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