A direct synthesis of atractylodinol, a potent inhibitor of PRRSV, and its biological evaluation

TETRAHEDRON LETTERS

卷:57

Article

Kraus, George A.¹  Dong, Pengfei¹  Qu, Yang¹  Evans, Alyssa²  Carpenter, Susan² 

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

[2] Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA

关键词: Total synthesis;    Atractylodinol;    PRRSV;    Antiviral activity;    In vitro;   

DOI  :  10.1016/j.tetlet.2016.10.014

来源: Elsevier

【 摘 要 】

A direct synthesis of atractylodinol from 2-furylbutenyne and bromoacetylene 6 is reported. Both compounds 1 and 8 showed greater than 99% virus inhibition. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free