Preparation of 2-(trimethylsilyl)methyl-2-propen-1-ol derivatives by cobalt catalyzed sp2-sp3 coupling

TETRAHEDRON LETTERS

卷:59

Article

Riaz, M. Tariq¹  Pohorilets, Ivanna¹  Hernandez, Jackson J.¹  Rios, Jeovanna¹  Totah, Nancy, I¹ 

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

关键词: Trimethylenemethane precursors;    Allylsilane;    Sp2-sp3 coupling;    Co catalyst;   

DOI  :  10.1016/j.tetlet.2018.06.018

来源: Elsevier

【 摘 要 】

A practical, operationally simple preparation of 2-(trimethylsilyl)methyl-2-propen-1-ol derivatives is described. The cobalt catalyzed coupling of a protected vinyl halide with trimethylsilylmethylmagnesium chloride shows excellent functional group tolerance and provides these synthetically useful allyl silanes in good overall yield. By this method, the use of highly concentrated organolithium reagents, complex reaction protocols, and expensive starting materials is avoided. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

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