Total synthesis and biological evaluation of marinopyrrole A and analogs

TETRAHEDRON LETTERS

卷:52

Article

Nicolaou, K. C.^1,2,3  Simmons, Nicholas L.^1,2  Chen, Jason S.^1,2  Haste, Nina M.⁴  Nizet, Victor^4,5 

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

关键词: Marine natural products;    Total synthesis;    Atropisomers;    Clauson-Kaas reaction;   

DOI  :  10.1016/j.tetlet.2010.09.059

来源: Elsevier

【 摘 要 】

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogs whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated. (C) 2010 Elsevier Ltd. All rights reserved.

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