Enantioselective bioreduction of ethyl 4,4,4-trihalide-3-oxobutanoate by Kluyveromyces marxianus

TETRAHEDRON LETTERS

卷:54

Article

de Sousa Oliveira, Simone Santos^1,2  Sousa Dias, Luiza Rosaria¹  Barbosa, Natane Cezario¹  Bello, Murilo L.¹  Moreira Novaes, Fabio Junior³  Ramos, Maria da Conceicao Klaus V.³  de Aquino Neto, Francisco Radler³  Fiaux, Sorele Batista² 

[1] Univ Fed Fluminense, Fac Farm, Lab Quim Med, BR-24241000 Niteroi, RJ, Brazil

[2] Univ Fed Fluminense, Fac Farm, Lab Tecnol Microbiana, BR-24241000 Niteroi, RJ, Brazil

[3] Univ Fed Rio de Janeiro, Inst Quim, LPCC LADETEC, Ctr Technol, BR-21949909 Rio De Janeiro, RJ, Brazil

关键词: Bioreduction;    Kluyveromyces marxianus;    Ethyl 4,4,4-trifluoro-3-oxobutanoate;    Ethyl 4,4,4-trichloro-3-oxobutanoate;   

DOI  :  10.1016/j.tetlet.2013.03.116

来源: Elsevier

【 摘 要 】

Resting cells of Kluyveromyces marxianus were used in the bioreduction of ethyl 4,4,4-trifluoro-3-oxobutanoate and ethyl 4,4,4-trichloro-3-oxobutanoate with 81% and 4% yields and 29% and 73% enantiomeric excess, respectively. The differences observed were attributed to the tri-halide structures. (C) 2013 Published by Elsevier Ltd.

【 授权许可】

Free