A novel method for the synthesis of 1-aryltetrahydroisoquinolines

TETRAHEDRON LETTERS

卷:58

Article

Ghanim, Amany M.^1,2  Knight, David W.¹  Rutkowski, Piotr M.¹  Osman, Nermine A.²  Abdel-Fattah, Hanan A.²  Kadry, Azza M.² 

[1] Cardiff Univ, Sch Chem, Main Coll, Park Pl, Cardiff CF10 3AT, S Glam, Wales

[2] Zagazig Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Zagazig 44519, Egypt

关键词: 1-Aryltetrahydroisoquinolines;    Carbenium ions;    Trapping;    Intramolecular;    Acid-catalysed;   

DOI  :  10.1016/j.tetlet.2016.11.115

来源: Elsevier

【 摘 要 】

Carbenium ions generated from substituted benzhydryls using acid catalysis undergo smooth intramolecular trapping by pendant sulfonamide groups to provide excellent yields of 1-aryltetrahydroisoquinolines. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

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