Kororamide A, a new tribrominated indole alkaloid from the Australian bryozoan Amathia tortuosa

TETRAHEDRON LETTERS

卷:53

Article

Carroll, Anthony R.^1,2  Wild, Seanan J.¹  Duffy, Sandra²  Avery, Vicky M.² 

[1] Griffith Univ, Environm Futures Ctr, Gold Coast, Qld 4222, Australia

[2] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

关键词: Bryozoan;    Alkaloid;    Indole;    Malaria;    Marine natural product;   

DOI  :  10.1016/j.tetlet.2012.03.126

来源: Elsevier

【 摘 要 】

A new tribrominated indole alkaloid, kororamide A together with the known alkaloid convolutamine F, were isolated through the application of mass directed purification from the bryozoan, Amathia tortuosa collected from northern New South Wales, Australia. The structure of kororamide A was deduced from the analysis of 1D/2D NMR and MS data. Kororamide A exists in solution as a mixture of interconverting cis-trans amide regioisomers in a ratio of 4:5. Bioactivity testing demonstrated that kororamide A was marginally active against chloroquine-sensitive and resistant strains of the malarial parasite Plasmodium falciparum, and was inactive against normal human cell lines. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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