Nonenzymatic enantioselective synthesis of all-carbon quaternary centers through desymmetrization

TETRAHEDRON LETTERS

卷:56

Article

Petersen, Kimberly S.¹ 

[1] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27402 USA

关键词: Desymmetrization;    All-carbon quaternary center;    Asymmetric;    Organocatalysis;    Transition-metal catalysis;   

DOI  :  10.1016/j.tetlet.2015.09.134

来源: Elsevier

【 摘 要 】

The asymmetric desymmetrization of mesa or prochiral compounds containing an all-carbon quaternary center is an attractive alternative to classical synthetic approaches aimed at the asymmetric formation of a new C-C bond. This review focuses on nonenzymatic desymmetrizations that utilize transition metal catalysts or organocatalysts to distinguish between enantiotopic groups to generate enantioenriched compounds containing all-carbon quaternary stereocenters. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free