A novel synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones

TETRAHEDRON LETTERS

卷:51

Article

Turbiak, Anjanette J.¹  Kampf, Jeff W.²  Showalter, H. D. Hollis¹ 

[1] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

关键词: Pyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione;    4-Deazatoxoflavin;    Phenylglyoxal;    Cyclizations;    6-(1-Methylhydiazinyl)uracil;   

DOI  :  10.1016/j.tetlet.2010.01.007

来源: Elsevier

【 摘 要 】

An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl)uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by selenium dioxide oxidation of the corresponding phenyl and alkyl methyl ketones. The first entry into 4-monosubstituted isomers is also reported. (C) 2010 Elsevier Ltd All rights reserved.

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