Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring

TETRAHEDRON LETTERS

卷:58

Article

Wallgren, Jakob¹  Vikingsson, Svante²  Johansson, Anders¹  Josefsson, Martin^1,3  Green, Henrik^2,3  Dahlen, Johan¹  Wu, Xiongyu¹  Konradsson, Peter¹ 

[1] Linkoping Univ, Dept Phys Chem & Biol, Linkoping, Sweden

[2] Linkoping Univ, Fac Hlth Sci, Dept Med & Hlth Sci, Div Drug Res, Linkoping, Sweden

[3] Linkoping Univ, Dept Forens Genet & Forens Toxicol, Natl Board Forens Med, Linkoping, Sweden

关键词: Admantane;    AKB-48;    Synthetic cannabinoid;    Metabolite;    Biomarker;   

DOI  :  10.1016/j.tetlet.2017.02.077

来源: Elsevier

【 摘 要 】

Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the synthesis and identification of one major metabolite of AKB-48, a new illicit psychoactive substance with a hydroxyl group at a secondary carbon of the adamantyl ring. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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