Preparation of phenalenes and hydronaphthacenes through tandem alkyne Fischer-carbene complex coupling and inter- or intra-molecular Diels-Alder reactions

TETRAHEDRON LETTERS

卷:52

Article

Patti, Rajesh Kumar¹  Duan, Shaofeng¹  Wang, Zhipeng¹  Herndon, James W.¹ 

[1] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA

关键词: Carbene complexes;    Isobenzofurans;    Cycloaddition;    Phenalenes;    Alkynes;    Naphthacenes;   

DOI  :  10.1016/j.tetlet.2011.06.006

来源: Elsevier

【 摘 要 】

The rapid construction of phenalenes through the reaction of 8-alkynyltetralones with Fischer-carbene complexes followed by either an inter- or intra-molecular Diels-Alder reaction is presented. As a showcase of the synthetic utility of this process, the rapid construction of polycyclic ring systems containing the tetracycline core has been demonstrated through an iterative application of this reaction sequence. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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