Copper-catalyzed four-component synthesis of imidazo[1,2-a]pyridines via sequential reductive amination, condensation, and cyclization

TETRAHEDRON LETTERS

卷:58

Article

Allahabadi, Emad¹  Ebrahimi, Sina¹  Soheilizad, Mehdi²  Khoshneviszadeh, Mehdi³  Mahdavi, Mohammad¹ 

[1] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran 14176, Iran

[2] Univ Tehran, Sch Chem, Coll Sci, POB 14155-6455, Tehran, Iran

[3] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran

关键词: Copper-catalyzed;    Imidazo[1,2-a]pyridine;    Reductive amination;    2-Bromopyridine;    Aldehyde;    Isocyanide;    Sodium azide;   

DOI  :  10.1016/j.tetlet.2016.11.081

来源: Elsevier

【 摘 要 】

A novel and efficient four -component approach for the synthesis of 2,3-disubstituted imidazo[1,2-a] pyridines is described. The copper -catalyzed reductive amination of 2-bromopyridine by sodium azide followed by sequential condensation and cyclization with aldehydes and isocyanides afforded the corresponding imidazo[1,2-alpyridines in good yields. (C) 2016 Elsevier Ltd. All rights reserved.

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