Recent developments on creation of artificial metalloenzymes

TETRAHEDRON LETTERS

卷:60

Article

Matsuo, Takashi¹  Miyake, Teruyuki¹  Hirota, Shun¹ 

[1] Nara Inst Sci & Technol NAIST, Grad Sch Sci & Technol, Div Mat Sci, Nara 6300192, Japan

关键词: Artificial metalloenzyme;    Diels-Alder reaction;    Olefin metathesis;    Cyclopropanation;   

DOI  :  10.1016/j.tetlet.2019.151226

来源: Elsevier

【 摘 要 】

Organic synthesis using biocatalysts has been developed over many years and is still a prominent area of research. In this context, various hybrid biocatalysts composed of a synthetic metal complex catalyst and a protein scaffold (i.e. artificial metalloenzymes) have been constructed. One of the most recent research areas in biocatalysts-mediated synthesis is C-C bond/cleavage, the most important type of reaction in organic chemistry. Some of the artificial enzymes were applied to in-cell reactions as well as in vitro systems. The effects of the structural fluctuation in biomacromolecules on their functions have also been realized. This review article includes recent research examples of artificial metalloenzymes used to C-C bond formation/cleavage, As a perspective, we also focus on how we apply protein dynamics factor for the creation of new generation artificial metalloenzymes. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free