A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation

TETRAHEDRON LETTERS

卷:52

Article

Gardiner, John M.¹ 

[1] Univ Manchester, Sch Chem, Manchester M1 7DN, Lancs, England

关键词: C-Glycosides;    Multivalency;    Carbohydrates;    Glycobiology;    Glycoconjugation;   

DOI  :  10.1016/j.tetlet.2011.04.047

来源: Elsevier

【 摘 要 】

Divergent synthesis of two novel C-glycosidic multivalent mannosides derived from a common trivalent C-mannosyl carboxylate-terminated intermediate is described. This illustrates synthesis of multivalent C-glycosidic architectures bearing variable extended functionalized tethers. One such tether incorporates an embedded fluorescent unit providing a C-mannosyl multivalent epitope offering potential applications through further conjugation or immobilization. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free