Parallel synthesis of structurally diverse aminobenzimidazole tethered sultams and benzothiazepinones

TETRAHEDRON LETTERS

卷:53

Article

Dadiboyena, Sureshbabu¹  Nefzi, Adel^1,2 

[1] Torrey Pines Inst Mol Studies, Port St Lucie, FL 34987 USA

[2] Florida Atlantic Univ, Boca Raton, FL 33431 USA

关键词: Solid-phase synthesis;    Aminobenzimidazoles;    Sultams;    Cyclic sulfonamides;    Benthiazepinones;    Intramolecular cyclization;    Heterocycles;   

DOI  :  10.1016/j.tetlet.2012.09.135

来源: Elsevier

【 摘 要 】

A solid-phase methodology to construct aminobenzimidazole tethered sultams and benzothiazepinones from commercial amino acids, amines, carboxylic acids, and sulfonyl chlorides is described. Coupling of Fmoc-Cys(Trt)-OH to resin-bound aminobenzimidazole scaffold provided an essential precursor for the construction of a variety of seven membered benzofused cyclic sulfonamides and thiazepinones via palladium catalyzed Buchwald-Hartwig type intramolecular cyclization. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free