Ruthenium-catalyzed rearrangement of propargyl sulfoxides: formation of α,β-unsaturated thioesters

TETRAHEDRON LETTERS

卷:56

Article

Zheng, Renhua^1,2  Wang, Youliang²  Zhang, Liming² 

[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China

[2] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

关键词: Ketene;    Ru vinylidene;    Oxidation;    Thioester;   

DOI  :  10.1016/j.tetlet.2014.11.138

来源: Elsevier

【 摘 要 】

Our previously developed strategy of generating ketene intermediates via Ru-catalyzed intramolecular oxidation of terminal alkynes is applied to propargyl sulfoxides. The reaction undergoes interesting further rearrangement upon the ketene generation to afford alpha,beta-unsaturated thioesters in good to excellent yields in the reported cases. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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