Bismuth-catalyzed synthesis of 2-substituted quinazolinones

TETRAHEDRON LETTERS

卷:59

Article

Vemula, Sandeep R.¹  Kumar, Dinesh²  Cook, Gregory R.¹ 

[1] North Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA

[2] Natl Inst Pharmaceut Educ & Res NIPER Ahmedabad, Dept Med Chem, Gandhinagar 382355, Gujarat, India

关键词: Bismuth;    Catalysis;    Quinazolinone;    Green chemistry;    Condensation;   

DOI  :  10.1016/j.tetlet.2018.09.014

来源: Elsevier

【 摘 要 】

The bismuth-catalyzed oxidative condensation of aldehydes with 2-aminobenzamide under aerobic conditions is reported using ethanol as the solvent. Good to excellent isolated yields (68-95%) of the corresponding 2-substituted quinazolinones were obtained under mild reaction conditions with excellent functional group tolerance. The quinazolinones were further functionalized to afford N-allylated quinazolinones, 2-aminopyridine derivatives, and annulated polyheterocyclic compounds via transition-metal catalyzed reactions. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

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