Catalytic monoalkylation of 1,2-diols

TETRAHEDRON LETTERS

卷:50

Article

Maki, Toshihide¹  Ushijima, Nobuto¹  Matsumura, Yoshihiro¹  Onomura, Osamu¹ 

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaka, Yamanashi 8528521, Japan

关键词: Diol;    Alkylation;    Lewis acid;    Allylation;    Benzylation;   

DOI  :  10.1016/j.tetlet.2009.01.063

来源: Elsevier

【 摘 要 】

A catalytic monoalkylation of 1,2-diols by using a weak base has been developed. Copper(II) dichloride and boronic acids are effective catalysts for activating 1,2-diols in the presence of potassium carbonate as a base. Various 1,2-diols were selectively monoalkylated with allyl-, benzyl- and alkyl- halides in DMF by choosing a suitable catalyst for each 1,2-diols. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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