Formation of bi-aryls via a domino palladium catalysis

TETRAHEDRON LETTERS

卷:55

Article

Krishna, J.¹  Reddy, A. Gopi Krishna¹  Satyanarayana, G.¹ 

[1] Indian Inst Technol IIT Hyderabad, Dept Chem, Yeddumailaram 502205, Andhra Pradesh, India

关键词: [Pd]-catalysis;    Bi-aryls;    Domino;    1-(2-Bromopheny1)-2-methylpropan-1-ones;    (2-Bromophenyl)(cyclohexyl)methanones;   

DOI  :  10.1016/j.tetlet.2013.12.030

来源: Elsevier

【 摘 要 】

Synthesis of bi-aryls via a domino Pd-catalyzed reaction of 1-(2-bromopheny1)-2-methylpropan-1-ones/(2-bromophenyl)(cyclohexyl)methanones is presented. The mechanism of the reaction is believed to proceed through a five membered palladacycle that combines with a second molecule of halo-arene to yield the bi-aryls. This method is quite successful to deliver highly sterically crowded bi-aryls with dense functionalities on the aromatic rings. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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