One-pot, three-component synthesis of novel δ-sultam scaffolds via N-sulfonylation-intramolecular Michael sequences

TETRAHEDRON LETTERS

卷:52

Article

Ghandi, Mehdi¹  Nazari, Seyed Hadi¹  Bozcheloei, Abolfazl Hasani¹  Sadeghzadeh, Masoud¹  Kia, Reza^2,3 

[1] Univ Tehran, Sch Chem, Coll Sci, Tehran, Iran

[2] Islamic Azad Univ, Xray Crystallog Lab, Plasma Phys Res Ctr, Sci & Res Branch, Tehran, Iran

[3] Islamic Azad Univ, Dept Chem, Sci & Res Branch, Tehran, Iran

关键词: delta-Sultams;    Enaminones;    N-Sulfonylation;    Styrenesulfonyl chlorides;   

DOI  :  10.1016/j.tetlet.2011.09.146

来源: Elsevier

【 摘 要 】

The synthesis of novel delta-sultam scaffolds utilizing one-pot, three-component reactions of 1,3-dicarbonyl compounds, primary aliphatic amines and substituted styrenesulfonyl chlorides is reported. A variety of six-membered sultams are obtained in moderate to good yields presumably via N-sulfonylation-intramolecular Michael addition sequences. (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

Free