The isolation and synthesis of 3-chloro-4-hydroxy-phenylacetamide produced by a plant-associated microfungus of the genus Xylaria

TETRAHEDRON LETTERS

卷:46

Article

Davis, RA ; Watters, D ; Healy, PC

关键词: microfungus;    Xylaria sp.;    natural products;    3-chloro-4-hydroxyphenylacetamide;    3-chloro-4-hydroxyphenylacetic acid;    X-ray crystal structure;    synthesis;   

DOI  :  10.1016/j.tetlet.2004.12.057

来源: Elsevier

【 摘 要 】

Chemical investigations of the fermentation broth from the microfungus Xylaria sp. have afforded the new natural product 3-chloro-4-hydroxyphenylacetamide 1 and the previously reported fungal metabolite 3-chloro-4-hydroxyphenylacetic acid 2. This letter reports the isolation and full spectroscopic characterisation of compounds 1 and 2 by NMR, UV, IR and MS data. The crystal structure and one-pot synthesis of 3-chloro-4-hdroxyphenylacetamide are also reported. (C) 2004 Elsevier Ltd. All rights reserved.

【 授权许可】

Free