An improved synthesis of a fluorescent gabapentin-choline conjugate for single molecule detection

TETRAHEDRON LETTERS

卷:50

Article

Wu, Haitao¹  Kaur, Gurpreet¹  Griffiths, Gary L.¹ 

[1] NHLBI, Imaging Probe Dev Ctr, NIH, Rockville, MD 20850 USA

关键词: Calcium ion channel;    Gabapentin;    Single molecule detection;    Fluorescence imaging;   

DOI  :  10.1016/j.tetlet.2009.02.125

来源: Elsevier

【 摘 要 】

Voltage-gated calcium ion channels comprise pore-forming alpha(1) and auxiliary alpha(2)delta, beta, and gamma subunits. They are important molecular devices involved in a variety of cell functions. Fluorescently labeled acylcholine analogues are important in studies such as ion channel regulation. Cy3-3-acetylcholine has recently been synthesized for single molecule detection studies; albeit in an extremely low overall yield (0.06%). In this Work, an alternative route to that used in the previous Cy3-3-acetylcholine synthesis was developed with a 90% yield at a significantly lower material cost. Published by Elsevier Ltd.

【 授权许可】

Free