Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales

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Article

Ayers, Sloan¹  Ehrmann, Brandie M.¹  Adcock, Audrey F.²  Kroll, David J.²  Wani, Mansukh C.³  Pearce, Cedric J.⁴  Oberlies, Nicholas H.¹ 

[1] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27402 USA

[2] N Carolina Cent Univ, Dept Pharmaceut Sci, BRITE, Durham, NC 27707 USA

[3] Res Triangle Inst, Nat Prod Lab, Res Triangle Pk, NC 27709 USA

[4] Mycosynthetix Inc, Hillsborough, NC 27278 USA

关键词: Fungi;    Cytotoxicity;    Benzoate;    Thielavin;    APPI;   

DOI  :  10.1016/j.tetlet.2011.08.125

来源: Elsevier

【 摘 要 】

As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

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