Edonamides, the first secondary metabolites from the recently described myxobacterium Aggregicoccus edonensis

TETRAHEDRON LETTERS

卷:56

Article

Karwehl, Sabrina^1,2  Mohr, Kathrin I.^1,2  Jansen, Rolf^1,2  Sood, Sakshi¹  Bernecker, Steffen^1,2  Stadler, Marc^1,2 

[1] Helmholtz Ctr Infect Res, Dept Microbial Drugs, D-38124 Braunschweig, Germany

[2] German Ctr Infect Res DZIF, Partner Site Hannover Braunschweig, Braunschweig, Germany

关键词: Myxobacteria;    DSM 27872(T);    Secondary metabolites;    Styrylamide;    NMR;   

DOI  :  10.1016/j.tetlet.2015.09.139

来源: Elsevier

【 摘 要 】

Two fatty acid styryl amides, edonamides A (1) and B (2), were isolated as the first secondary metabolites from the recently described myxobacterial genus and family Aggregicoccus edonensis. Their molecular structures were elucidated using extensive HRESIMS and NMR analyses. Since edonamides A (1) and B (2) did not show inhibitory activity against different bacteria, fungi, and cell lines a role as signaling molecules in the life cycle of myxobacteria seems possible. (C) 2015 Elsevier Ltd. All rights reserved.

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