Synthesis of indoles through acceptorless dehydrogenative coupling catalyzed by nickel on silica-alumina

TETRAHEDRON LETTERS

卷:78

Article

Charvieux, Aubin¹  Hammoud, Abdul Aziz¹  Duclos, Marie-Christine¹  Duguet, Nicolas¹  Metay, Estelle¹ 

[1] Univ Lyon, Univ Claude Bernard Lyon 1, CNRS,Inst Chim & Biochim Mol & Supramol, UMR 5246,INSA Lyon,CPE Lyon,ICBMS,Equipe Catalyse, Campus Lyon Tech Doua,Batiment Lederer, F-69100 Villeurbanne, France

关键词: Indole;    Acceptorless dehydrogenative coupling;    Heterogeneous nickel;    Anilines;    Diols;   

DOI  :  10.1016/j.tetlet.2021.153270

来源: Elsevier

【 摘 要 】

The high atom-economical formation of indoles from anilines and diols was described with affordable and easy to handle Ni/SiO2-Al2O3. After optimization, 2,3-dimethylindole was isolated with an excellent 98% yield in neat conditions. The scope of the reaction was studied and 13 indoles were isolated in 16-80% yields. (C) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

Free