An efficient microwave assisted synthesis of novel class of Rhodanine derivatives as potential HIV-1 and JSP-1 inhibitors

TETRAHEDRON LETTERS

卷:52

Article

Kamila, Sukanta¹  Ankati, Haribabu¹  Biehl, Edward R.¹ 

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

关键词: 3-Phenyl-2-thioxothiazolidin-4-one;    2-(1H-Indol-3-yl)-2-oxoacetaldehyde;    Acid chloride;    HSnBu(3);    MW irradiation;   

DOI  :  10.1016/j.tetlet.2011.05.114

来源: Elsevier

【 摘 要 】

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one (7a-q) derivatives have been synthesized by the condensation reaction of 3-phenyl-2-thioxothiazolidin-4-ones (3a-h) with suitably substituted 2-(1H-indo1-3-yl)-2-oxoacetaldehyde (6a-d) under microwave condition. The thioxo-thiazolidine-4-ones were prepared from the corresponding aromatic amines (la-e) and di-(carboxy-methyl)-trithiocarbonyl (2). The aldehydes (6a-h) were synthesized from the corresponding acid chlorides (5a-d) using HSnBu(3). (C) 2011 Elsevier Ltd. All rights reserved.

【 授权许可】

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