期刊论文详细信息
TETRAHEDRON LETTERS 卷:57
Synthesis of oxetane/azetidine containing spirocycles via the 1,3-dipolar cycloaddition reaction
Article
Jones, Benjamin1  Proud, Mitchell1  Sridharan, Visuvanathar1 
[1] Univ Leeds, Sch Chem, Leeds LS2 9J, W Yorkshire, England
关键词: Oxetane;    Azetidine;    1,3 dipolar cycloaddition;    Spirocycle;    Multicomponent reaction;   
DOI  :  10.1016/j.tetlet.2016.05.053
来源: Elsevier
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【 摘 要 】

Silver catalyzed 1,3-dipolar cycloaddition reactions between methyl 2-(oxetane/azetidine-3 ylidene) acetate as dipolarophiles and imines derived from alpha-amino acid methyl esters, 2-aminomethyl pyridine, and 2-aminomethyl pyrazine afforded oxetane/azetidine containing spirocycles in 40-77% yield. The use of 3-oxetanone used as the carbonyl compound thermal 1,3-dipolar cycloaddition reactions with secondary alpha-amino acids or methyl esters resulted in oxetane spirocycles in 62-90% yield. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.

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