Flash production of organophosphorus compounds in flow

TETRAHEDRON LETTERS

卷:81

Article

Tamaki, Takashi¹  Nagaki, Aiichiro¹ 

[1] Kyoto Univ, Grad Sch Engn, Dept Synthet Chem & Biol Chem, Nishikyo Ku, Kyoto 6158510, Japan

关键词: Flow synthesis;    Phosphate ester;    Phosphite ester;    High productivity;    Flash chemistry;   

DOI  :  10.1016/j.tetlet.2021.153364

来源: Elsevier

【 摘 要 】

Flow synthesis techniques have received a significant amount of attention due to their high productivity. However, when reaction condition is heterogeneous, it is usually difficult to adapt it to flow synthesis. Herein, by selecting appropriate reagents, the synthesis of phosphate esters, which is commonly heterogeneous, was made homogeneous, enabling synthesis in flow systems. In addition, reaction rate was accelerated compared to the batch system. It was demonstrated that not only can the high productivity of flow synthesis be achieved in flow, but also high productivity can be achieved by accelerating the reaction. Finally, we demonstrated the synthesis of the Akiyama-Terada catalyst, a chiral organocatalysts, in a short period. (c) 2021 Published by Elsevier Ltd.

【 授权许可】

Free