Total synthesis of (-)-mniopetal E, a novel biologically intriguing drimane sesquiterpenoid

TETRAHEDRON LETTERS

卷:40

Article

Suzuki, Y ; Nishimaki, R ; Ishikawa, M ; Murata, T ; Takao, K ; Tadano, K

关键词: biologically active compounds;    Diels-Alder reactions;    terpenoids;   

DOI  :  10.1016/S0040-4039(99)01631-7

来源: Elsevier

【 摘 要 】

Total synthesis of (-)-mniopetal E, the common skeleton of the biologically intriguing mniopetals A-D, was accomplished for the first time. The key step of the total synthesis was stereoselective intramolecular Diels-Alder reaction for construction of the octahydronaphthalene core structure. Our total synthesis as natural enantiomeric form established the unsettled absolute stereochemistry of the antibiotic. (C) 1999 Elsevier Science Ltd. All rights reserved.

【 授权许可】

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