An efficient synthesis of 3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline, a promising radioprotector for cancer radiotherapy

TETRAHEDRON LETTERS

卷:55

Article

Wu, Haitao¹  Coble, Vincent¹  Vasalatiy, Olga¹  Swenson, Rolf E.¹  Krishna, Murali C.²  Mitchell, James B.² 

[1] NHLBI, Imaging Probe Dev Ctr, NIH, Rockville, MD 20850 USA

[2] NCI, Radiat Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

关键词: Nitroxide;    Redox;    Radioprotector;    MRI;    EPRI;   

DOI  :  10.1016/j.tetlet.2014.08.028

来源: Elsevier

【 摘 要 】

Nitroxides can ameliorate the toxic effects of radiation during cancer therapy. Nitroxides are paramagnetic and can be used in magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI) to monitor in vivo oxidative stress status. Compound 5 (3-(N-piperidinemethyl)-2,2,5,5-tetramethyl-1-oxy-3-pyrroline) was found to be the most effective nitroxide radioprotector. An efficient synthesis for this promising radioprotector was developed. Published by Elsevier Ltd.

【 授权许可】

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